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Gallstone prevalence in Germany: the Ulm Gallbladder Stone Study

W Kratzer1, V Kächele, R A Mason

  • 1Department of Internal Medicine, Institute for Clinical Chemistry, University of Ulm, Germany.

Digestive Diseases and Sciences
|July 4, 1998
PubMed
Summary

The Ulm Gallbladder Stone Study found 6.0% prevalence of gallbladder disease in West German blood donors. Gallstone prevalence increased with age, BMI, and family history, but not significantly with gender.

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Area of Science:

  • Epidemiology
  • Gastroenterology
  • Medical Imaging

Background:

  • Gallstones (cholelithiasis) are a common condition with varying prevalence globally.
  • Ultrasound is a primary diagnostic tool for detecting gallstones.
  • Epidemiologic data on gallstone prevalence in Germany, particularly from ultrasound surveys, are limited.

Purpose of the Study:

  • To determine the prevalence of gallbladder disease (cholelithiasis) in a West German population using ultrasound.
  • To investigate the correlation of gallstone prevalence with age, gender, body mass index (BMI), and family history.
  • To compare ultrasound-based findings with existing autopsy data.

Main Methods:

  • A cross-sectional study involving 1116 blood donors in Ulm, Germany (April 1994 - February 1995).

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  • Subjects were interviewed and underwent ultrasound examination and blood tests.
  • Participants were stratified into four age groups (18-65 years).

    • Main Results:

    • Overall prevalence of gallbladder disease was 6.0% (5.8% men, 6.3% women).
    • Prevalence increased significantly with age (13.7% in 51-65 year olds) and BMI.
    • A positive family history of gallstones was associated with higher prevalence (11.5% vs. 4.6%).

    Conclusions:

    • The Ulm Gallbladder Stone Study provides the first ultrasound-based prevalence data for gallstones in former West Germany.
    • Age, family history, and BMI are significant risk factors for gallbladder disease.
    • The observed prevalence is lower than some German autopsy studies, potentially due to differences in study populations and methodologies.