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Updated: Jul 22, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Myocardial perfusion after coronary artery bypass surgery. A study using ectomographic myocardial scintigraphy and

R E Anderson1, D Bone, S M Dale

  • 1Department of Cardiothoracic Anesthetics, Karolinska Hospital, Stockholm, Sweden. russell.anderson@kirurgi.ki.se

Scandinavian Cardiovascular Journal : SCJ
|June 24, 1998
PubMed

Insights

Myocardial perfusion significantly improves one year after coronary artery bypass graft (CABG) surgery, with reversible ischemia largely eliminated. Resting perfusion defects decrease substantially, indicating long-term benefits of CABG.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Cardiovascular Surgery

Background:

  • Coronary artery bypass graft (CABG) surgery aims to restore myocardial perfusion.
  • The time course of perfusion recovery and resolution of reversible ischemia post-CABG requires detailed investigation.

Purpose of the Study:

  • To evaluate the time-dependent changes in myocardial perfusion after CABG surgery.
  • To assess the resolution of reversible ischemia using adenosine stress testing post-CABG.

Main Methods:

  • Seventeen patients with 3-vessel disease underwent myocardial scintigraphy with Tc99m-sestamibi at rest and during adenosine infusion preoperatively and post-CABG (1 hour, 1 week, 1 year).
  • Ectomographic myocardial scintigraphy assessed isotope uptake defect size and reduction.
  • Adenosine infusion was used to provoke reversible ischemia.

Main Results:

  • Resting perfusion defects were unchanged at 1 hour post-CABG, worsened at 1 week, but decreased by 24% at 1 year compared to pre-CABG.
  • Adenosine-induced reversible ischemia, significant pre-CABG, was eliminated post-CABG in all regions.
  • No significant difference in perfusion was observed between arterial and venous graft territories.

Conclusions:

  • Myocardial perfusion demonstrates significant improvement up to one year after CABG surgery.
  • Adenosine-induced reversible ischemia is effectively resolved following CABG.
  • The study highlights the long-term functional recovery of myocardial perfusion post-CABG.

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