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Photodynamic therapy

T J Dougherty1, C J Gomer, B W Henderson

  • 1Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, NY, USA.

Journal of the National Cancer Institute
|June 24, 1998
PubMed
Summary
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Photodynamic therapy uses a light-activated photosensitizing agent to destroy tumor tissues. This established cancer treatment has gained regulatory approval in multiple countries for various cancers.

Area of Science:

  • Oncology
  • Biochemistry
  • Photomedicine

Background:

  • Photodynamic therapy (PDT) is a treatment modality that utilizes photosensitizing agents and light to induce tumor cell death.
  • Over 25 years of research, PDT has demonstrated efficacy in preclinical and clinical studies for various cancers.

Purpose of the Study:

  • To provide a comprehensive review of the expanding field of photodynamic therapy.
  • To discuss the mechanisms, localization, and cellular responses involved in PDT.
  • To address technical aspects of light dosimetry in PDT.

Main Methods:

  • Review of preclinical and clinical studies on photodynamic therapy.
  • Discussion of photosensitizing agent properties, including metabolic synthesis (prodrugs) and tumor localization.

Related Experiment Videos

  • Analysis of molecular, cellular, and tumor responses to PDT.
  • Consideration of light dosimetry techniques.

    • Main Results:

    • Photodynamic therapy involves administering a tumor-localizing photosensitizer, followed by light activation.
    • This process triggers photochemical and photobiologic events leading to irreversible photodamage in tumor tissues.
    • Regulatory approval for PDT using Photofrin has been obtained in several countries since 1993 for lung, digestive, and genitourinary tract cancers.

    Conclusions:

    • Photodynamic therapy is an established and expanding treatment approach for certain cancers.
    • Understanding the mechanisms of photosensitizer localization and tumor response is crucial for effective PDT.
    • Further research and technical considerations, such as light dosimetry, are important for optimizing PDT outcomes.