Related Experiment Videos
Polygenic control of the expression of biological activities of an antitumor polysaccharide, lentinan
Y Y Maeda1, S Takahama, Y Kohara
1Department of Laboratory Animal Science, The Tokyo Metropolitan Institute of Medical Science, Japan. maeda@rinshoken.or.jp
International Journal of Immunopharmacology
|June 24, 1998
Abstract:
Genetic studies were carried out on two in vivo responses of lentinan, delayed type-acute phase responses (DT-APR) and vascular dilation and hemorrhage (VDH). Linkage analyses showed that DT-APR was controlled by two recessive genes, ltnr1 and ltnr2, which were mapped on chromosome 3 and 11, respectively. VDH was also found to be controlled by polygenes. One dominant major gene, Ltnr3, and three dominant minor genes, Ltnr4, Ltnr5, and Ltnr6, were mapped on chromosomes 6, 9, 15 and 16, respectively.