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Related Experiment Videos

Myc activates telomerase

J Wang1, L Y Xie, S Allan

  • 1Cold Spring Harbor Laboratory (CSHL), Cold Spring Harbor, New York 11724, USA.

Genes & Development
|June 24, 1998
PubMed
Summary
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The oncogene Myc activates the enzyme telomerase, which is crucial for cancer cell survival. This discovery sheds light on how tumors maintain their telomeres and potentially form.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Telomere maintenance is critical for human tumor development.
  • Telomerase is a marker for tumor cells, but its activation mechanism during neoplastic transformation is unclear.

Purpose of the Study:

  • To investigate the role of Myc in telomerase activation during neoplastic transformation.
  • To identify the genetic alterations that activate telomerase in cancer cells.

Main Methods:

  • Utilized normal human mammary epithelial cells (HMECs) and normal human diploid fibroblasts.
  • Assessed the effect of Myc on telomerase expression and activity.
  • Measured the impact of Myc and hEST2 on cellular lifespan.

Main Results:

Related Experiment Videos

  • Myc was shown to induce telomerase in both HMECs and fibroblasts.
  • Myc increases the expression of hEST2 (human telomerase reverse transcriptase), the rate-limiting subunit of telomerase.
  • Both Myc and hEST2 were found to extend the lifespan of HMECs.

Conclusions:

  • Myc-induced telomerase activation is a key event in cellular immortalization.
  • The ability of Myc to activate telomerase may contribute to its role in promoting tumor formation.
  • Understanding this mechanism provides insights into cancer development and potential therapeutic targets.