Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Olfactory G proteins: simple and complex signal transduction

F A Ebrahimi1, A Chess

  • 1Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.

Current Biology : CB
|June 25, 1998
PubMed
Summary

Olfactory perception relies on G-protein-coupled receptors in many species. New research reveals how specific G proteins influence smell, neuron shape, and nerve pathway development in mice and C. elegans.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary complications in primary hypogammaglobulinemia: a survey by high resolution CT scan.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace·2006
Same author

Dscam-mediated self- versus non-self-recognition by individual neurons.

Cold Spring Harbor symposia on quantitative biology·2005
Same author

Asynchronous replication and allelic exclusion in the immune system.

Nature·2001
Same author

Convergent projections of Drosophila olfactory neurons to specific glomeruli in the antennal lobe.

Nature neuroscience·2000
Same author

Allele-specific expression patterns of interleukin-2 and Pax-5 revealed by a sensitive single-cell RT-PCR analysis.

Current biology : CB·2000
Same author

Odorant receptors: axon contact-mediated diversity.

Current biology : CB·2000

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Olfactory perception, crucial for survival, is primarily mediated by G-protein-coupled receptors (GPCRs) across diverse species.
  • Understanding the specific roles of associated signaling proteins is key to deciphering olfactory mechanisms.

Purpose of the Study:

  • To elucidate the function of specific G proteins in the olfactory system.
  • To investigate the impact of G proteins on neuronal morphology and axon guidance in olfactory pathways.

Main Methods:

  • Utilized genetic models in mouse and Caenorhabditis elegans.
  • Investigated olfactory signal transduction pathways.
  • Analyzed neuronal morphology and axon guidance in olfactory neurons.

Main Results:

  • Identified specific G proteins critical for olfactory signal transduction.
  • Demonstrated the involvement of these G proteins in shaping olfactory neuron morphology.
  • Showcased the role of G proteins in directing olfactory axon guidance.

Conclusions:

  • Specific G proteins are essential regulators of olfactory perception.
  • These G proteins play multifaceted roles, influencing not only signal transduction but also neuronal development and connectivity.

Related Experiment Videos