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[Hereditary cancer]

A L Børresen-Dale1, H Boman

  • 1Avdeling for genetikk, Det Norske Radiumhospital Montebello, Oslo.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|June 25, 1998
PubMed
Summary

Inherited cancer susceptibility involves genetic predispositions and environmental factors. Advances in identifying cancer-susceptible genes are improving genetic testing for cancer risk.

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Area of Science:

  • Oncology
  • Genetics
  • Cancer Research

Context:

  • A significant proportion of cancers are inherited or occur in genetically susceptible individuals.
  • Understanding genetic predisposition is crucial for cancer etiology.
  • Environmental factors interact with genetic susceptibility in cancer development.

Purpose:

  • To provide an updated overview of inherited cancer, including monogenic syndromes and familial cancer patterns.
  • To outline cellular mechanisms of cancer initiation and progression.
  • To discuss the implications of identifying cancer-susceptible genes for genetic testing.

Summary:

  • Reviews inherited cancer syndromes (monogenic, autosomal recessive, autosomal dominant) and gene-environment interactions.
  • Explains the cellular basis of cancer initiation and progression.
  • Highlights the growing number of identified cancer-susceptible genes and their role in predictive genetic testing.

Impact:

  • Facilitates a deeper understanding of hereditary cancer risk.
  • Informs the development and application of novel genetic tests for cancer.
  • Addresses the benefits and challenges of predictive genetic testing in cancer management.

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