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[Multiple bilateral biopsy of the prostate]
P Pavlica1, L Barozzi, S Dalla Rovere
1Servizio di Radiologia, Ospedale M. Malpighi, Bologna.
La Radiologia Medica
|June 25, 1998
Summary
Systematic biopsies detect prostate cancer in normal-appearing areas, aiding staging and Gleason grading. Elevated PSA values can help select patients for this diagnostic technique.
Area of Science:
- Urology
- Oncology
- Diagnostic Imaging
Context:
- Transrectal ultrasound (US)-guided biopsy is standard for prostate cancer detection.
- Systematic bilateral biopsies offer improved local staging and Gleason grading.
- Assessing neoplastic lesions in visually normal prostate areas is crucial for accurate diagnosis.
Purpose:
- To determine the frequency of cancers in prostate areas appearing normal on US and rectal examination.
- To identify criteria for selecting patients for random prostate biopsies.
- To evaluate the utility of systematic biopsies in detecting prostate malignancies.
Summary:
- Systematic bilateral biopsies identified cancer in 34.19% of patients with elevated PSA and suspected lesions.
- Unilateral cancer was found in 66% and bilateral cancer in 34% of positive cases.
- Prostate-specific antigen (PSA) values showed statistically significant differences between benign, unilateral, and bilateral carcinoma groups.
Impact:
- Systematic US-guided biopsies are useful for detecting tumors in areas without apparent abnormalities.
- Further studies are needed to confirm the clinical utility and long-term outcomes.
- PSA levels may serve as a criterion for patient selection, providing valuable preoperative information.