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Haemodynamic evaluation of cerebral gliomas using XeCT
T Nakagawa1, R Tanaka, S Takeuchi
1Department of Neurosurgery, Niigata University, Japan.
Acta Neurochirurgica
|June 25, 1998
Summary
Stable xenon-enhanced computed tomography (XeCT) reveals distinct blood flow patterns in cerebral gliomas. These patterns, varying between high-grade and low-grade gliomas, may aid in pre-operative histopathological assessment.
Area of Science:
- Neuroimaging
- Radiology
- Oncology
Background:
- Cerebral gliomas (CG) exhibit diverse histopathological features.
- Accurate pre-operative characterization of CG is crucial for treatment planning.
Purpose of the Study:
- To characterize regional blood flow (BF) in untreated CG using stable xenon-enhanced computed tomography (XeCT).
- To correlate XeCT findings with histopathological characteristics of CG.
Main Methods:
- XeCT analysis of 38 patients with untreated CG.
- Comparison of XeCT data with CT, MRI, and histopathological findings.
- Assessment of BF values in tumor, cyst, necrosis, and surrounding cortex.
Main Results:
- Averaged BF in gliomas was intermediate between cortex and white matter.
- Cyst and necrosis showed very low BF.
- High-grade gliomas (HGGs) showed high BF in ring-enhancement but low BF in non-enhanced centers.
- Low-grade gliomas (LGGs) exhibited homogeneous low BF in small lesions and heterogeneous BF in large lesions.
Conclusions:
- XeCT can differentiate BF patterns in untreated CG.
- Observed BF differences between HGGs and LGGs may assist in pre-operative histopathological assessment.