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Neuron-specific enolase: reference values in cord blood

K Kintzel1, J Sonntag, E Strauss

  • 1Abteilung für Neonatologie, Humboldt-Universität, Berlin, Germany.

Clinical Chemistry and Laboratory Medicine
|June 25, 1998
PubMed
Summary
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Prenatal ultrasound increasingly detects fetal tumors. This study establishes neuron-specific enolase (NSE) reference values in cord blood for early postnatal neuroblastoma diagnosis in newborns.

Area of Science:

  • Neonatal Medicine
  • Biochemistry
  • Pediatric Oncology

Background:

  • Prenatal diagnosis of fetal tumors via sonography is rising.
  • Accurate postnatal identification of fetal tumors is crucial for timely evaluation and treatment.
  • Neuron-specific enolase (NSE) is a key biochemical marker for neuroblastoma, but birth-related factors necessitate specific cord blood reference values.

Purpose of the Study:

  • To establish reference ranges for neuron-specific enolase (NSE) concentration in healthy term newborn cord blood.
  • To provide a basis for early postnatal diagnosis of neuroblastoma.

Main Methods:

  • Cord blood samples were collected from 192 healthy, full-term newborns.
  • Neuron-specific enolase (NSE) concentrations were quantified using enzyme immunoassay (EIA).

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Main Results:

  • The median NSE concentration in the reference cord blood group was 8.0 µg/L.
  • The 5th-95th percentile range for NSE in cord blood was determined to be 4.8-19.4 µg/L.
  • No statistically significant difference in NSE levels was observed between male and female newborns (p = 0.13).

Conclusions:

  • Established NSE cord blood reference values enable early postnatal confirmation of neuroblastoma.
  • This diagnostic approach aids in the prompt management of infants with suspected neuroblastoma detected prenatally.