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Flow-injection spectrophotometric determination of diclofenac sodium in pharmaceuticals and urine samples
M S García1, M I Albero, C Sánchez-Pedreño
1Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, Spain.
Journal of Pharmaceutical and Biomedical Analysis
|June 25, 1998
Abstract:
A sensitive and fast flow-injection spectrophotometric method for the determination of diclofenac sodium based on the formation of coloured compound with Ce(IV)-3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in H2SO4 3 x 10(-2) M medium is proposed. Using the peak height as a quantitative parameter diclofenac was determined at 580 nm over the range 0.20-8.0 micrograms ml-1. The proposed method was successfully applied to the determination of diclofenac in pharmaceuticals and urine samples.