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The effects of haemofiltration on cefazolin levels during cardiopulmonary bypass

J J O'Rullian1, R K Wise, R M McCoach

  • 1College of Medicine, Pennsylvania State University, Hershey, USA.

Perfusion
|June 25, 1998
PubMed

Insights

Ultrafiltration during cardiopulmonary bypass (CPB) does not significantly alter cefazolin antibiotic levels, suggesting it does not increase sternal wound infection risk. Routine CPB procedures with ultrafiltration are safe regarding antibiotic efficacy.

Area of Science:

  • Cardiovascular Surgery
  • Pharmacology
  • Infectious Disease

Background:

  • Ultrafiltration (UF) during cardiopulmonary bypass (CPB) can alter drug concentrations.
  • Sternal wound infections are a concern following cardiac surgery.
  • The impact of UF on antibiotic levels and infection risk requires clarification.

Purpose of the Study:

  • To investigate the effect of ultrafiltration on cefazolin concentrations during CPB.
  • To determine if ultrafiltration increases the risk of sternal wound infections.

Main Methods:

  • A comparative study of cefazolin levels during routine CPB with and without ultrafiltration.
  • Measurement of antibiotic concentrations at three time intervals.
  • Comparison with a control group not undergoing ultrafiltration.

Main Results:

  • Minimal difference observed in the rate of cefazolin level decay with or without ultrafiltration.
  • Ultrafiltration via a haemoconcentrator did not significantly impact antibiotic pharmacokinetics.
  • No increased risk for infection was indicated by antibiotic levels.

Conclusions:

  • Ultrafiltration during CPB does not appear to compromise cefazolin levels.
  • The use of ultrafiltration in CPB is unlikely to increase the risk of sternal wound infections.
  • Standard institutional practices are sufficient; additional infection control measures are not necessitated by UF use.

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