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Cytokines orchestrating the immune response

J K Lunney1

  • 1Immunology and Disease Resistance Laboratory, United States Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Maryland 20705-2350, USA.

Revue Scientifique Et Technique (International Office of Epizootics)
|June 25, 1998
PubMed
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Cytokines are key immune regulators. Genetic variations in cytokine responses impact disease resistance and recovery in livestock and poultry, with emerging clinical applications in veterinary medicine.

Area of Science:

  • Immunology and Genetics
  • Veterinary Medicine
  • Biotherapeutics

Background:

  • Cytokines are crucial for regulating immune responses.
  • Understanding genetic factors influencing disease resistance is vital for livestock and poultry.
  • Cytokine research is expanding with new agonists and antagonists.

Purpose of the Study:

  • To summarize current knowledge on immune cytokines, receptors, and functions.
  • To highlight the role of cytokines in disease resistance and pathology.
  • To discuss the clinical applications of cytokines in veterinary medicine.

Main Methods:

  • Literature review and synthesis of existing research on cytokines.
  • Analysis of genetic factors affecting cytokine expression and responsiveness.

Related Experiment Videos

  • Exploration of current and future clinical trials involving cytokines.

    • Main Results:

    • Cytokines play a pivotal role in immune response regulation.
    • Genetic variations in cytokine pathways influence disease resistance, pathology, and recovery.
    • Cytokine-based biotherapeutics are under active clinical investigation for various species.

    Conclusions:

    • Genetic control of cytokine responses is critical for disease management in animals.
    • Future veterinary practice will increasingly involve cytokine-based therapies.
    • Producers need to consider genetic predispositions to cytokine stimulation.