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The effect of cardiopulmonary bypass on blood cell filterability in children undergoing cardiac surgery
P Bergman1, A Belboul, L G Friberg
1Department of Thoracic and Cardiovascular Surgery, Sahlgrenska Hospital, University of Gothenburg, Sweden.
Insights
Pediatric cardiac surgery using cardiopulmonary bypass (CPB) causes blood trauma, altering blood cell rheology. These changes persist post-surgery, indicating potential long-term effects in children undergoing heart procedures.
Area of Science:
- Pediatric Cardiac Surgery
- Cardiovascular Research
- Hematology
Background:
- Cardiopulmonary bypass (CPB) in cardiac surgery can cause blood damage, affecting blood cell rheology.
- Assessing blood trauma in pediatric patients is challenging due to limited sample volumes.
- Understanding blood trauma is crucial for evaluating new surgical and extracorporeal techniques in children.
Purpose of the Study:
- To assess blood cell rheology changes in pediatric patients undergoing cardiac surgery with CPB.
- To evaluate the impact of CPB on blood trauma in children with congenital heart disease.
Main Methods:
- Studied fourteen pediatric patients undergoing cardiac surgery for congenital heart disease correction.
- Monitored whole blood, red blood cell, and white blood cell rheology (filterability) before, during, and after CPB.
- Utilized the St. George filtrometer for rheological assessments with small blood sample volumes.
Main Results:
- All measured rheologic parameters were significantly altered during CPB.
- Rheologic parameters remained outside established reference values throughout the CPB procedure.
- Blood trauma effects were evident before, during, and after CPB in pediatric patients.
Conclusions:
- Blood cell rheologic disturbances associated with CPB do not show rapid recovery post-procedure.
- These findings suggest potential long-term implications for pediatric patients.
- Further follow-up is needed to understand recovery patterns after pediatric heart surgery involving CPB.
Background:
The extended use of cardiopulmonary bypass (CPB) in cardiac surgery is limited because of damage to blood which in adults has been assessed by alterations in blood cell rheology. Blood trauma assessment in children is difficult because of the restrictions in sample volume and frequency but needs to be established from time to time in order to study the tolerance to new surgical and extracorporeal techniques.
Materials And Methods:
Fourteen pediatric patients undergoing cardiac surgery with CPB for congenital heart disease corrections were studied. Whole blood, red blood cell and white blood cell rheology (filterability) were monitored before, during and after CPB using the St. George filtrometer that used small amounts of blood.
Results:
The results showed that all the rheologic parameters were altered during the blood trauma of CPB and were outside the reference values before, during and after CPB.
Conclusions:
This suggested that blood cell rheologic disturbances did not recover soon after CPB and this may be of interest in long term follow-up to understand responses and recovery patterns to disease and interventions associated with pediatric heart surgery using CPB.