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Risperidone for young children with mood disorders and aggressive behavior

H A Schreier1

  • 1Department of Psychiatry at Children's Hospital-Oakland, California 94609, USA.

Journal of Child and Adolescent Psychopharmacology
|June 25, 1998
PubMed
Summary

Risperidone shows promise for treating children and adolescents with mood disorders and aggression. This medication, often used with mood stabilizers, demonstrated therapeutic responses in 73% of patients with minimal side effects.

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Area of Science:

  • Child and Adolescent Psychiatry
  • Psychopharmacology
  • Neurodevelopmental Disorders

Background:

  • Investigated risperidone's efficacy in children and adolescents with complex behavioral and affective symptoms.
  • Addressed inadequate response to traditional mood-stabilizing medications.

Observation:

  • Open clinical treatment involved 11 children and adolescents (5.5-16 years) with affective symptoms, aggression, and management issues.
  • Patients exhibited symptoms suggestive of bipolar disorder and inadequate response to prior treatments.

Findings:

  • 8 of 11 children (73%) showed therapeutic responses to low-dose risperidone (0.75-2.5 mg/day).
  • Improvements were moderate to marked in 7 of 8 responders, often within days.
  • Side effects were minimal, primarily mild sedation and weight gain; 2 children discontinued due to drowsiness.

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Implications:

  • Risperidone may be a valuable treatment option for pediatric mood disorders with aggressive behavior.
  • Combination therapy with mood stabilizers warrants further investigation.
  • Preliminary findings suggest potential benefits for subthreshold bipolar disorder in youth.