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Clarithromycin induced digoxin toxicity

S P Nordt¹, S R Williams, A S Manoguerra

¹California Poison Control System-San Diego Division and Division of Medical Toxicology University of California, San Diego Medical Center, 92103-8925, USA. snordt@ucsd.edu

Journal of Accident & Emergency Medicine

|June 25, 1998

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A 28-year-old male experienced digoxin poisoning when taking digoxin with clarithromycin. This case highlights a critical drug-drug interaction between digoxin and clarithromycin, often overlooked in chronic digoxin poisoning.

Area of Science:

Pharmacology
Clinical Toxicology

Background:

Digoxin is a cardiac glycoside used for heart failure and arrhythmias.
Chronic digoxin poisoning often presents with unclear etiology.
Clarithromycin is a macrolide antibiotic with known drug interaction potential.

Observation:

A case report details a 28-year-old male patient.
The patient was co-administered digoxin and clarithromycin.
This led to an episode of digoxin poisoning.

Findings:

The co-administration of digoxin and clarithromycin resulted in digoxin toxicity.
This interaction underscores a potential cause for unexplained chronic digoxin poisoning.

Implications:

Related Experiment Videos

Clinicians must be aware of the potential for drug-drug interactions between digoxin and clarithromycin.

This interaction can lead to serious adverse events, including digoxin poisoning.

Consideration of concomitant medications is crucial in managing patients on digoxin.