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Estrogen-induced tumorigenesis in the pituitary gland of TGF-beta(+/-) knockout mice
N Shida1, H Ikeda, T Yoshimoto
1Department of Neurosurgery, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980, Japan.
Biochimica Et Biophysica Acta
|June 26, 1998
Abstract:
Transforming growth factor (TGF)-beta receptor type II gene (Tgfbr2) knockout and wild type mice underwent chronic estrogen exposure using estradiol pellets. Histological examination of the pituitary glands found 38 adenomas in 14 Tgfbr2(+/-) mice but only one tumor in ten wild type mice. Pituitary tumorigenesis is greatly accelerated in Tgfbr2(+/-) mice by estrogen treatment.