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[The mechanisms of progesterone treatment on endometrial carcinoma]
Zhonghua Fu Chan Ke Za Zhi
|July 1, 1997
Abstract
Objective:
To study the mechanisms of the exogenic progestrerone treatment on endometrial carcinoma.
Methods:
We observed the morphologic changes of the endometrial cancer cells treated by exogenic progesterone with light and electronic microscopy.
Results:
The main changes of the tumor cell treated were well differentiation, increase in secretory activity and apoptosis of tumor cells.
Conclusions:
Progesterone may directly affect tumor cells, inhibit the growth of tumor cells and lead to well differentiation. Clinically with preoperative and postoperative progesterone therapy, it can decrease the peritoneum implantation and metastasis, and also decrease the recurrence after operation.