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An experimental comparative study on the characteristics of ventricular fibrillation during cardiac arrest and
1Department of Thoracic and Cardiac Surgery, Tongji Hospital, Tongji Medical University, Wuhan. Wuhan.
Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao
|January 1, 1997
Abstract:
The effect of a pure alpha-adrenergic agent, methoxamine on ventricular fibrillation (VF) amplitude and the relation between hemodynamic parameters and survival in a rodent cardiopulmonary resuscitation (CPR) model were studied. Our results suggested that: 1) VF amplitude decreased during untreated VF, but it increased during pericardial chest compression: 2) methoxamine significantly increased the mean aortic pressure (MAP) and coronary perfusion pressure (CPP) but not VF amplitude, and the survival also increased due to elevation of CPP; and 3) all surviving animals with successful defibrillation had a higher VF amplitude.