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Synthesis and preliminary antileukemic studies of cyclic mitoguazone analogues
1Department of Pharmaceutical Chemistry and Drug Analysis, Medical Academy, Lódź, Poland.
Farmaco (Societa Chimica Italiana : 1989)
|June 26, 1998
Abstract:
Analogues of mitoguazone bearing a terminal amidino group as a part of the seven-membered ring of 1,3-diazepine and six-membered ring of pyrimidine were prepared in order to evaluate in vivo antileukemic action towards L1210 leukemia in mice. Preliminary pharmacological screening showed that the investigated compounds increase the life span (T/C%) of the treated mice in comparison with the untreated animals. The strongest antineoplastic effect was exhibited by compound 8.