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Related Experiment Videos

'Diprifusor' for neurosurgical procedures

N J Huggins1

  • 1Featherstone Department of Anaesthesia, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK.

Anaesthesia
|June 26, 1998
PubMed
Summary

Target controlled infusion of propofol (Diprifusor) offers advantages in neurosurgery for rapid cognitive recovery. This method enables anesthesia induction without significant hemodynamic or respiratory compromise in neurosurgical patients.

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Area of Science:

  • Anesthesiology
  • Neurosurgery
  • Pharmacokinetics

Background:

  • Propofol's pharmacokinetic profile is beneficial for neurosurgery.
  • Early postoperative neurological assessment requires rapid cognitive function return.

Purpose of the Study:

  • To evaluate the 'Diprifusor' target controlled infusion system for neuroanesthesia.
  • To compare 'Diprifusor' with manual propofol infusion in neurosurgical patients.

Main Methods:

  • Administration of propofol using 'Diprifusor' target controlled infusion.
  • Induction of anesthesia in 20 neurosurgical patients undergoing craniotomy.
  • Comparison with 10 patients receiving manually controlled propofol infusion.

Main Results:

  • 'Diprifusor' allowed anesthesia induction without significant reduction in mean arterial pressure.
  • Apnoeic episodes were not observed during 'Diprifusor' administration.
  • The study compared outcomes with manual propofol infusion control.

Conclusions:

  • 'Diprifusor' target controlled infusion is a viable option for neuroanesthesia.
  • This method facilitates early neurological assessment due to rapid cognitive recovery.
  • It provides stable hemodynamics and respiratory function during neurosurgery.

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