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Related Experiment Videos

Future applications for TCI systems

S E Milne1, G N Kenny

  • 1University Department of Anaesthesia, Glasgow Royal Infirmary, UK.

Anaesthesia
|June 26, 1998
PubMed
Summary
This summary is machine-generated.

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Target controlled infusion (TCI) systems, like the Diprifusor, are increasingly used for propofol administration. Future applications include patient-controlled analgesia/sedation and closed-loop propofol systems, with alfentanil and remifentanil showing promise.

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Biomedical Engineering

Background:

  • Target controlled infusion (TCI) systems, utilizing the 'Diprifusor', are gaining traction for propofol administration.
  • The increasing availability and use of TCI necessitate exploration of its broader applications and performance with various drugs and control strategies.

Purpose of the Study:

  • To review future applications of TCI technology.
  • To summarize findings from prototype TCI systems used with different control techniques and drugs.
  • To evaluate the suitability of specific analgesic drugs for TCI.

Main Methods:

  • Review of studies utilizing prototype TCI systems.
  • Analysis of patient-controlled systems for analgesia and sedation.
  • Examination of closed-loop control systems for propofol administration.

Related Experiment Videos

  • Assessment of analgesic drugs for TCI compatibility.

    • Main Results:

    • Prototype TCI systems have been studied for patient-controlled analgesia/sedation and closed-loop propofol delivery.
    • Alfentanil and remifentanil are identified as suitable for TCI based on their pharmacokinetic properties.
    • Commercial TCI systems for alfentanil and remifentanil are not yet available.

    Conclusions:

    • TCI technology, particularly with propofol, has potential for expanded clinical use beyond current applications.
    • Further development is needed for commercial TCI systems for specific analgesics like alfentanil and remifentanil.
    • TCI offers promising avenues for advanced drug administration strategies in anesthesia and critical care.