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TCI compared with manually controlled infusion of propofol: a multicentre study
1Department of Anaesthesia, University Hospital Centre, Hôpital Bichat, Paris, France.
Anaesthesia
|June 26, 1998
Summary
Target controlled infusion (TCI) of propofol required lower induction doses compared to manual control. While TCI administration rates were higher, most anaesthetists preferred TCI for its ease of use in surgical procedures.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Propofol is a widely used intravenous anaesthetic agent.
- Manual infusion requires continuous adjustment by the anaesthetist.
- Target controlled infusion (TCI) systems aim to maintain a specific drug concentration in the body.
Purpose of the Study:
- To compare the clinical profile of 'Diprifusor' TCI propofol with manually controlled infusion.
- To evaluate propofol dosage, administration, and anaesthetist preference in a multicentre setting.
Main Methods:
- Prospective, randomised multicentre study involving 562 patients undergoing various surgical procedures.
- Comparison of propofol induction dose and administration rate between TCI and manual infusion groups.
- Analysis of factors influencing target concentration (CT) and investigator preference.
Main Results:
- TCI required a significantly lower propofol dose for loss of consciousness (1.69 vs. 2.31 mg.kg-1, p < 0.001).
- Overall propofol administration rate was slightly higher with TCI (12.1 vs. 11.0 mg.kg-1.h-1, p < 0.05).
- Investigator preference strongly favoured TCI (93% overall, 76% found it easier to use).
Conclusions:
- TCI of propofol demonstrates a favourable clinical profile, requiring lower induction doses.
- Anaesthetist preference indicates TCI may become a preferred method for propofol administration.
- Clinical performance of TCI may improve with increased anaesthetist experience and active titration.