Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diabetic retinopathy in Down's syndrome

T Fulcher1, M Griffin, S Crowley

  • 1Department of Ophthalmology, Mater Misericordiae Hospital, Dublin, Ireland.

The British Journal of Ophthalmology
|June 26, 1998
PubMed
Summary

Patients with Down syndrome and diabetes mellitus show a low prevalence of diabetic retinopathy, even with long-term diabetes. This suggests a potential protective factor in this population against diabetic eye disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: A novel extracellular role for tissue transglutaminase in matrix-bound VGF-mediated angiogenesis.

Cell death & disease·2026
Same author

Post-Pneumonectomy Syndrome.

Irish medical journal·2025
Same author

Management strategies following recurrence of resected retroperitoneal sarcoma: A 10-year observational study.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2025
Same author

Exploring the Pathways to Diagnosis for Men With Borderline Personality Disorder: A Qualitative Study.

International journal of mental health nursing·2024
Same author

A Randomised Phase II Trial of Hippocampal Sparing Versus Conventional Whole Brain Radiotherapy After Surgical Resection or Radiosurgery in Favourable Prognosis Patients With 1-10 Brain Metastases.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same author

Comparative assessment of radiation therapy-induced vasculitis using [<sup>18</sup>F]FDG-PET/CT in patients with non-small cell lung cancer treated with proton versus photon radiotherapy.

European journal of nuclear medicine and molecular imaging·2023

Area of Science:

  • Ophthalmology
  • Endocrinology
  • Genetics

Background:

  • Diabetes mellitus is a leading cause of blindness worldwide.
  • Diabetic retinopathy is a common complication of diabetes.
  • Down syndrome is associated with various health conditions, but its impact on diabetic complications is less understood.

Purpose of the Study:

  • To investigate the prevalence of diabetic retinopathy in individuals with Down syndrome and diabetes mellitus.
  • To explore potential factors influencing diabetic retinopathy in this specific patient group.

Main Methods:

  • A cohort of nine patients with Down syndrome and diabetes mellitus was evaluated.
  • Data collected included diabetes type and duration, glycemic control, blood pressure, urinalysis, and ophthalmological examinations.

Related Experiment Videos

Main Results:

  • The study included patients with diabetes duration ranging from 8 to 41 years.
  • All patients demonstrated satisfactory glycemic control and low-normal blood pressure.
  • Only one patient exhibited early background diabetic retinopathy; the rest showed no signs of the condition.

Conclusions:

  • A surprisingly low prevalence of diabetic retinopathy was observed in patients with Down syndrome and diabetes mellitus.
  • This finding suggests a possible inherent protective mechanism against diabetic retinopathy in individuals with Down syndrome.