Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Angiosarcoma arising in a chronically lymphoedematous leg

S A Sinclair¹, L Sviland, S Natarajan

¹Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.

The British Journal of Dermatology

|June 26, 1998

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Influence of hybrid fiber reinforcement on strength and durability properties of fly ash blended PSC concrete.

Scientific reports·2026

Same author

Pottery art therapy for chronic schizophrenia: Impact on negative symptoms, quality of life, and social skills in a randomized controlled trial.

Journal of education and health promotion·2026

Same author

A smart compliance validation framework for steel reinforcement in concrete structures using web extension technology.

Scientific reports·2026

Same author

Assessing functional and radiological outcomes: open reduction and internal fixation vs. minimally invasive plate osteosynthesis for humerus shaft fractures - a prospective comparative study.

International orthopaedics·2024

Same author

Implementing teleophthalmology services to improve cost-effectiveness of the national eye care system.

Eye (London, England)·2024

Same author

Addition of nisin to high-viscosity glass-ionomer cement: a comparative in vitro study on antibacterial and physical properties.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2024

A rare, aggressive cutaneous angiosarcoma developed in an 86-year-old woman with chronic leg lymphedema. This aggressive cancer of endothelial cells led to rapid decline and death within five months.

Area of Science:

Oncology
Dermatology
Vascular Biology

Background:

Cutaneous angiosarcoma is a rare, aggressive vascular tumor originating from endothelial cells.
It commonly presents on the head, neck, or extremities as papules or nodules.
Chronic lymphedema is a known, albeit uncommon, risk factor for angiosarcoma development.

Observation:

An 86-year-old woman with a 40-year history of chronic immobility-related lymphedema of the right leg presented with a leg tumor.
The tumor manifested as a plaque on the lower leg and foot, with satellite lesions on the knee and groin.
Initially, satellite lesions were mistaken for petechial hemorrhages but rapidly grew into tumor nodules.

Findings:

Histological examination confirmed moderately to poorly differentiated angiosarcoma in all tumor specimens.

Related Experiment Videos

The angiosarcoma arose in the context of long-standing, unilateral lymphedema.

No preceding malignancy or prior operative intervention to the affected limb was identified.

Implications:

This case highlights a rare presentation of cutaneous angiosarcoma.
It underscores the importance of considering angiosarcoma in patients with chronic lymphedema, particularly when lesions appear unusual or rapidly change.
The aggressive nature of this tumor necessitates prompt diagnosis and management, as evidenced by the patient's rapid decline.