Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Telomeres, the nucleolus and aging

F B Johnson1, R A Marciniak, L Guarente

  • 1Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA. bjohnson@mit.edu

Current Opinion in Cell Biology
|June 26, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The financial burden of healthcare-associated infections: a propensity score analysis in an Italian healthcare setting.

Infection prevention in practice·2025
Same author

Not only COVID-19: a systematic review of anti-COVID-19 measures and their effect on healthcare-associated infections.

The Journal of hospital infection·2024
Same author

G-quadruplex dynamics contribute to regulation of mitochondrial gene expression.

Scientific reports·2019
Same author

Novel and Haplotype Specific MicroRNAs Encoded by the Major Histocompatibility Complex.

Scientific reports·2018
Same author

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production.

Oncogene·2011
Same author

Thermal-blooming compensation using the CLASP system.

Applied optics·2010

Reactivating telomerase extends human cell life, while yeast aging involves the nucleolus and ribosomal DNA circles. Researchers are exploring if these mechanisms apply to human aging.

Area of Science:

  • Cellular biology
  • Gerontology
  • Molecular genetics

Background:

  • Telomere shortening is linked to cellular senescence and organismal aging.
  • The Hayflick limit describes the finite number of cell divisions.
  • The nucleolus and ribosomal DNA (rDNA) are implicated in aging in model organisms like yeast.

Purpose of the Study:

  • To investigate the role of telomere shortening in triggering cellular senescence.
  • To explore the contribution of telomere shortening to aging in vivo.
  • To examine the relevance of nucleolar function and rDNA circle accumulation to human aging.

Main Methods:

  • Culturing human cells to observe replicative life span.
  • Investigating telomere dynamics and senescence pathways.

Related Experiment Videos

  • Studying yeast models to understand nucleolar roles in aging.
  • Analyzing ribosomal DNA circle formation and its impact.

    • Main Results:

    • Reactivation of telomerase in human cells extends replicative life span beyond the Hayflick limit.
    • Telomere shortening's role in senescence and in vivo aging is under active investigation.
    • Ribosomal DNA circle accumulation is identified as a cause of aging in yeast.

    Conclusions:

    • Telomerase activity is a key factor in extending cellular replicative potential.
    • The nucleolus and associated mechanisms may represent conserved pathways in aging.
    • Further research is needed to determine the direct applicability of yeast aging mechanisms to humans.