Some thoughts and observations concerning the prevention of neuroma

Reliable prevention of neuroma is a problem the solution of which is still outstanding. Compared to earlier methods, which mostly consisted in attempts to stop axonal proliferation abruptly, it is now coming to be generally accepted that the regenerative potential of the axons needs to be reduced gradually. The methods most in accord with this view--centro-central anastomosis and capping of nerve ends with a nerve or vein graft--are considered, adding personal observations. A new variant that has shown special promise in animal experiments involves using a nerve and a vein graft in combination. The method still requires clinical verification.