Unusual neuropsychiatric manifestations of hypoparathyroidism: report of two cases

Clinical, laboratory and radiological features of two cases of hypoparathyroidism presenting with pure neurological disease are described. The first patient has choreoathetosis and the second has mutism, locked jaw bilateral papilloedema and generalised tonic clonic epilepsy. Computerised tomography of the brain showed extensive calcification in the gray and white matter in both cases. Such combination of neurological manifestation of the disease and extensive cerebral calcification is rarely encountered and reported. It is concluded that brain calcification, which is generally believed to be asymptomatic, can cause frank neurological disease when it is extensive.