Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tracheobronchial amyloidosis

B Papla1, M Dubiel-Bigaj

  • 1Department of Experimental and Clinical Pathomorphology, CMUJ, Kraków.

Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists
|June 26, 1998
PubMed
Summary

Tracheobronchial amyloidosis was studied in eleven patients. Transthyretin (prealbumin) amyloid was identified in six cases, with some cases linked to bronchial carcinoma.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chromosomal markers as prognostic indicators in transitional-cell carcinomas of the bladder.

International journal of oncology·2011
Same author

[Myoepitheliomas of the palate].

Otolaryngologia polska = The Polish otolaryngology·2005
Same author

The history of the Chair and Department of Pathological Anatomy at the Jagiellonian University and School of Medicine in Kraków on the 150th anniversary of its foundation.

Polish journal of pathology : official journal of the Polish Society of Pathologists·2002
Same author

Glomus tumour of the oesophagus.

Polish journal of pathology : official journal of the Polish Society of Pathologists·2002
Same author

[A case of tracheal adenoid cystic carcinoma in a young woman].

Pneumonologia i alergologia polska·2001
Same author

[Pulmonary lymphangioleiomyomatosis as a very rare interstitial lung disease].

Polskie Archiwum Medycyny Wewnetrznej·2001

Area of Science:

  • Pulmonary Medicine
  • Pathology
  • Immunohistochemistry

Background:

  • Tracheobronchial amyloidosis is a rare condition.
  • Understanding the specific amyloid protein types involved is crucial for diagnosis and management.

Purpose of the Study:

  • To characterize eleven cases of tracheobronchial amyloidosis.
  • To identify the specific types of amyloid protein present using immunohistochemistry.
  • To explore potential associations with bronchial carcinoma.

Main Methods:

  • Clinical and histopathological review of eleven tracheobronchial amyloidosis cases.
  • Immunohistochemical analysis for amyloid AA, AL, transthyretin (prealbumin), and beta 2-microglobulin.
  • Correlation of amyloid type with clinical presentation and presence of bronchial carcinoma.

Main Results:

  • Transthyretin (prealbumin) was the predominant amyloid type, found in six of eleven cases.
  • Other amyloid types (AA, AL, beta 2-microglobulin) were not detected.
  • Resorptive giant cell reaction was observed in four cases.
  • Four cases, all men, showed negative amyloid results for transthyretin and were associated with bronchial carcinoma.

Conclusions:

  • Transthyretin (prealbumin) is a common type of amyloid found in tracheobronchial amyloidosis.
  • A subset of tracheobronchial amyloidosis, particularly in men, may be associated with bronchial carcinoma and negative for transthyretin.
  • Further research is needed to elucidate the relationship between amyloidosis subtypes and malignancy.

Related Experiment Videos