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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Differences between women and men with chronic renal disease
C H Coggins1, J Breyer Lewis, A W Caggiula
1Massachusetts General Hospital and Harvard Medical School, USA.
Summary
Women in the Modification of Diet in Renal Disease (MDRD) study showed slower kidney function decline than men. Gender differences may impact the effectiveness of interventions for slowing renal disease progression.
Area of Science:
- Nephrology
- Clinical Trials
- Gender Medicine
Background:
- The Modification of Diet in Renal Disease (MDRD) study was a multicenter prospective randomized clinical trial.
- Understanding gender participation and outcomes in renal disease research is crucial.
Purpose of the Study:
- To compare male and female participation in the MDRD study.
- To assess gender-specific differences in renal outcomes and intervention responses.
Main Methods:
- Subgroup analysis of 840 MDRD participants (332 women).
- Comparison of recruitment, baseline characteristics, adherence, safety, outcomes, and disease progression between genders.
- Evaluation of responses to dietary protein and blood pressure interventions.
Main Results:
- Women's adherence to study protocols was equivalent to men's.
- Women exhibited slower rates of glomerular filtration rate (GFR) decline, particularly younger women.
- Adjusting for blood pressure, proteinuria, and HDL cholesterol attenuated the gender difference in GFR decline.
- No significant gender differences in intervention effects on the full cohort; some evidence of lesser effects in women in study A.
Conclusions:
- Women demonstrated a slower mean GFR decline compared to men in the MDRD study.
- Suggestive evidence indicates potentially lesser benefits from low-protein and low-blood-pressure interventions in women.
- Gender considerations are important in trials investigating interventions for renal disease progression.
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