Related Experiment Videos
Catheter complications associated with intraperitoneal chemotherapy
1Institute of Oncology, Department of Medical Oncology, University of Istanbul, Capa, Turkey.
European Journal of Gynaecological Oncology
|June 26, 1998
Summary
Single-use catheters (SUC) had higher overall complication rates than semi-permanent subcutaneous implantable port and catheter systems (SIPC) in intraperitoneal chemotherapy. SIPC showed more pain, infection, and obstruction, while SUC had more colon punctures and leakage.
Area of Science:
- Oncology
- Surgical Oncology
- Medical Devices
Background:
- Intraperitoneal chemotherapy is used for intra-abdominal malignancies.
- Catheter systems are crucial for delivering chemotherapy effectively and safely.
- Different catheter types may present varying complication profiles.
Purpose of the Study:
- To compare the complication rates and types between single-use catheters (SUC) and semi-permanent subcutaneous implantable port and catheter systems (SIPC).
- To evaluate the safety and efficacy of these two catheter systems in patients undergoing intraperitoneal chemotherapy for intra-abdominal malignancies.
Main Methods:
- Retrospective analysis of 171 patients with primary intra-abdominal malignancies.
- Comparison of complication data between 96 patients using SUC (1990-1993) and 75 patients using SIPC (1993-1996).
- Analysis of chemotherapy regimens including cisplatin, 5-fluorouracil, calcium folinate, etoposide, and mitoxantrone.
Main Results:
- Significantly higher overall complication incidence in SUC (45%) compared to SIPC (23%) (p=0.001).
- SUC showed higher rates of colon puncture (8.8%) and subcutaneous leakage (3.7%).
- SIPC had higher rates of pain (6%), local infection (1.4%), and obstruction (1.4%). Intra-abdominal fibrosis and adhesions were more severe with SIPC.
Conclusions:
- Significant differences exist in complication rates and types between SUC and SIPC for intraperitoneal chemotherapy.
- While SUC had more procedural complications, SIPC was associated with more post-procedural issues like pain, infection, and obstruction, and severe fibrosis.
- A randomized trial is necessary to definitively determine the real complication rates, safety, efficacy, and acceptability of these catheter systems.