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Colchicine for recurrent pericarditis in children

A Yazigi1, L C Abou-Charaf

  • 1Department of Paediatrics, St. George Hospital, Beirut, Lebanon.

Acta Paediatrica (Oslo, Norway : 1992)
|June 26, 1998
PubMed
Summary

Colchicine effectively treats recurrent pericarditis in children unresponsive to other therapies. This approach shows promising long-term results with no adverse reactions, offering a new treatment option for pediatric cases.

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Area of Science:

  • Pediatric Cardiology
  • Infectious Diseases
  • Rheumatology

Background:

  • Recurrent acute pericarditis affects 15-30% of children, leading to significant morbidity.
  • Current treatments like NSAIDs and corticosteroids have variable success and side effects.
  • Colchicine has shown promise in adult recurrent pericarditis, but pediatric data is lacking.

Observation:

  • Three children with recurrent pericarditis, refractory to NSAIDs/corticosteroids, were treated with colchicine.
  • Treatment duration was 6 months.
  • No adverse reactions were reported during colchicine therapy.

Findings:

  • All three children demonstrated remarkable improvement with colchicine treatment.
  • Patients remained well 11-18 months after discontinuing colchicine.
  • This suggests colchicine is a safe and effective option for pediatric recurrent pericarditis.

Implications:

  • Colchicine offers a novel, well-tolerated therapeutic option for pediatric recurrent pericarditis.
  • This study supports further investigation into colchicine's role in managing pediatric inflammatory cardiac conditions.
  • Findings may reduce long-term morbidity associated with recurrent pericarditis in children.

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