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Anti-acetylcholinesterase antibody in myasthenic syndrome
1Department of Neurology, First Affiliated Hospital of Beijing Medical University, China.
Objective:
To examine the relationship between antibodies to acetylcholinesterase and myasthenic syndrome.
Methods:
Serum class specific antibodies to acetylcholinesterase and acetylcholine receptor were prepared with solid phase enzyme-linked immunosorbent assay in 51 patients with myasthenic syndrome, 31 controls with other neurological diseases (diseased controls) and 44 normal controls.
Results:
The positive rate of anti-acetylcholinesterase antibody in patients with myasthenic syndrome was 25%, while the results of the other two control groups were negative. Furthermore, the positive rate in patients without myasthenia gravis was 45%, which was much higher than that (13%) in those with myasthenic gravis.
Conclusion:
Anti-acetylcholinesterase antibody may play a role in the pathogenesis of myasthenic syndrome.