[Spasmolytic effects of crebanine on isolated gallbladder and Oddi's sphincter in vitro]

The study has shown that the contraction induced by histamine, Ca2+ and K+ in the biliary system of guinea-pigs is antagonized by crebanine in vitro. The antagonism presents a depression of the maximal response of the dose-response curve for the agonists in a non-competitive manner. Crebanine blocks the release of calcium from intracellular storage on isolated gall-bladder. The spontaneous activity of the oddi's sphincter in vitro is inhibited by crebanine. The initial phasic and the ionic contraction induced by K+ (40 mmol/L) in the isolated oddi's sphincters of guinea-pigs are inhibited by crebanine.