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Related Experiment Videos

Final height in long-term primary hypothyroid children

A Chiesa1, L Gruñeiro de Papendieck, A Keselman

  • 1Centro de Investigaciones Endocrinológicas, Hospital de Niños R. Gutiérrez, Buenos Aires, Argentina.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|June 27, 1998
PubMed
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Children with primary hypothyroidism treated before puberty achieved normal adult height relative to their target height. However, those treated during puberty did not achieve catch-up growth, indicating puberty

Area of Science:

  • Pediatric Endocrinology
  • Growth and Development
  • Thyroid Disorders

Background:

  • Primary hypothyroidism in children can significantly impair statural growth.
  • Early diagnosis and treatment are crucial for optimizing growth outcomes.
  • Understanding the impact of treatment timing on final height is essential.

Purpose of the Study:

  • To retrospectively analyze the statural growth and bone maturation in children with primary hypothyroidism.
  • To correlate final height with chronological age, height deficit, and bone age at treatment initiation.
  • To evaluate the influence of treatment timing (prepubertal vs. pubertal) on achieving target height.

Main Methods:

  • Retrospective study of 32 children diagnosed with primary hypothyroidism.

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  • Patients were categorized into three groups based on age at treatment initiation: early childhood (G1), late childhood (G2), and puberty (G3).
  • Final height was compared to target height, with analysis of height deficits and bone age progression.

    • Main Results:

    • Children treated before puberty (G1 and G2) achieved final heights comparable to their target heights (SDS G1: -1.05 +/- 0.89; G2: -1.2 +/- 1).
    • Children treated during puberty (G3) did not reach their target height (SDS G3: -2 +/- 1.5), with a statistically significant difference (p < 0.04).
    • Bone age advancement varied, with prepubertal groups showing better catch-up potential.

    Conclusions:

    • Treatment of primary hypothyroidism initiated before puberty allows for attainment of normal adult height relative to genetic potential.
    • Puberty is a critical period, and its onset in untreated or inadequately treated hypothyroid children significantly hinders catch-up growth.
    • Timely intervention in pediatric hypothyroidism is paramount for achieving optimal growth outcomes.