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[Epidemiological study on penicillin-resistant Streptococcus pneumoniae]

S Yamasaki1, Y Sugimoto, Y Matsumoto

  • 1Third Department of Internal Medicine, Faculty of Medicine, Tottori University.

Kansenshogaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
|June 27, 1998
PubMed
Summary

Penicillin-resistant Streptococcus pneumoniae isolates, primarily serotype 19F, show altered pbp2b genes and share a common origin. These resistant strains have rapidly spread in Tottori University Hospital since 1991.

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Epidemiology

Context:

  • Penicillin resistance in Streptococcus pneumoniae is a growing public health concern.
  • Clinical isolates of Penicillin-resistant Streptococcus pneumoniae were collected from respiratory infections between 1986 and 1996.
  • Understanding the genetic basis and spread of resistant strains is crucial for effective treatment.

Purpose:

  • To investigate the genetic characteristics and clonal origins of penicillin-resistant Streptococcus pneumoniae isolates.
  • To determine the prevalence of altered pbp2b genes and specific serotypes among resistant strains.
  • To analyze the epidemiological spread of resistant strains within a hospital setting.

Summary:

  • Polymerase chain reaction (PCR) detected altered pbp2b genes in 76.5% of penicillin-resistant Streptococcus pneumoniae isolates, correlating with increased minimum inhibitory concentration (MIC).

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  • Serotyping revealed serotype 19F as the predominant type (54.5%) among resistant isolates, with a rapid increase in penicillin resistance noted from 1991.
  • Pulsed field gel electrophoresis (PFGE) analysis indicated a common clonal origin for most penicillin-resistant 19F isolates, suggesting rapid dissemination.

    • Impact:

    • Identifies a specific clonal group of penicillin-resistant Streptococcus pneumoniae (serotype 19F) responsible for a rapid increase in resistance.
    • Highlights the importance of molecular typing methods like PCR and PFGE in tracking the spread of antibiotic-resistant bacteria.
    • Provides valuable data for infection control strategies and antibiotic stewardship programs to combat the rise of resistant pathogens.