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[Hyperbaric oxygen therapy for radiation-induced hemorrhagic cystitis]
1Department of Urology, Faculty of Medicine, University of The Ryukyus.
Summary
Hyperbaric oxygen therapy offers a beneficial treatment for radiation cystitis, a difficult complication of pelvic radiation therapy. This therapy improved symptoms and findings in patients with hemorrhagic cystitis.
Area of Science:
- Oncology
- Urology
- Hyperbaric Medicine
Context:
- Radiation therapy for pelvic cancers can lead to radiation cystitis.
- Hemorrhagic cystitis is a severe complication refractory to conventional treatments.
- Hyperbaric oxygen therapy (HBOT) is explored as a potential treatment.
Purpose:
- To evaluate the efficacy of hyperbaric oxygen therapy for radiation-induced hemorrhagic cystitis.
- To assess the safety and tolerability of HBOT in this patient population.
Summary:
- Ten patients with radiation cystitis underwent HBOT (20 sessions, 100% oxygen at 2 ATA).
- Seven patients experienced improvement in hematuria and urinary frequency.
- Cystoscopic findings showed partial improvement; overall palliation was observed in all patients.
Impact:
- HBOT provides a potentially effective, minimally invasive option for refractory radiation cystitis.
- This therapy may improve quality of life for cancer survivors experiencing late radiation effects.
- Further research may establish HBOT as a standard treatment for radiation-induced cystitis.