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Related Experiment Videos

[Transdermal fentanyl]

D Lossignol1, J Sternon

  • 1Unité de Soins Supportifs, Soins Palliatifs et de Réhabilitation, Institut Jules Bordet, U.L.B.

Revue Medicale De Bruxelles
|June 27, 1998
PubMed
Summary
This summary is machine-generated.

Fentanyl, a synthetic opioid agonist, effectively manages cancer pain via transdermal patches (TTS). While side effects are similar to morphine, it causes less constipation, with short-acting morphine recommended for breakthrough pain.

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Area of Science:

  • Pharmacology
  • Pain Management
  • Drug Delivery Systems

Context:

  • Fentanyl is a potent synthetic opioid agonist targeting mu-receptors.
  • Its lipophilicity enables transdermal drug delivery via Transdermal Therapeutic Systems (TTS).
  • Established clinical efficacy in managing cancer-related pain.

Purpose:

  • To summarize the pharmacological properties and clinical applications of fentanyl TTS.
  • To outline its efficacy and side effect profile in pain management.
  • To provide guidance on its use in conjunction with other analgesics.

Summary:

  • Fentanyl TTS offers effective and sustained delivery for chronic pain, particularly cancer pain.
  • Key side effects mirror morphine, with a notable reduction in constipation incidence.

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  • Concurrent use of short-acting morphine is advised for managing breakthrough pain episodes.

    • Impact:

    • Provides a concise overview of fentanyl TTS for healthcare professionals and researchers.
    • Highlights the therapeutic advantages and considerations for fentanyl in pain management.
    • Contributes to evidence-based practice in palliative and cancer pain care.