Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Giant cell arteritis

G G Hunder1

  • 1Mayo Clinic, Rochester, MN 55905, USA.

Lupus
|June 27, 1998
PubMed
Summary
This summary is machine-generated.

Giant cell arteritis (GCA) is a common vasculitis. Research suggests GCA involves an immune response to artery wall antigens, potentially triggered by infection, with genetic and age factors influencing susceptibility.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primary central nervous system vasculitis: comparison of patients with and without cerebral amyloid angiopathy.

Rheumatology (Oxford, England)·2008
Same author

Primary CNS vasculitis with spinal cord involvement.

Neurology·2008
Same author

Cervical interspinous bursitis in active polymyalgia rheumatica.

Annals of the rheumatic diseases·2008
Same author

Laboratory investigations useful in giant cell arteritis and Takayasu's arteritis.

Clinical and experimental rheumatology·2004
Same author

Vasculitis. A collection of pearls and myths.

Rheumatic diseases clinics of North America·2001
Same author

Giant cell arteritis with low erythrocyte sedimentation rate: frequency of occurence in a population-based study.

Arthritis and rheumatism·2001
Same journal

Recent advances in the management of pediatric neuropsychiatric lupus from conventional therapies to novel immunomodulators.

Lupus·2026
Same journal

Association of serum and urinary galectin-3 with renal fibrosis in patients with lupus nephritis: A cross-sectional controlled study.

Lupus·2026
Same journal

Continuation of belimumab in patients with systemic lupus erythematosus in a real-world setting: A single-center retrospective cohort study.

Lupus·2026
Same journal

Serum RIPK3/MLKL as exploratory biomarker candidates for systemic lupus erythematosus.

Lupus·2026
Same journal

Clinical and histopathological predictors of systemic lupus erythematosus in a South American cohort of patients with full-house glomerulonephritis.

Lupus·2026
Same journal

Longitudinal observation of thrombotic events in patients with obstetric antiphospholipid syndrome.

Lupus·2026
See all related articles

Area of Science:

  • Rheumatology
  • Immunology
  • Pathology

Background:

  • Giant cell arteritis (GCA) is the most prevalent form of vasculitis in many populations.
  • Susceptibility is linked to genetic markers, ethnicity, and age over 50.
  • Infections may act as a potential trigger for GCA onset.

Purpose of the Study:

  • To elucidate the underlying mechanisms of giant cell arteritis.
  • To explore the role of immune responses in GCA pathogenesis.
  • To understand factors contributing to GCA susceptibility.

Main Methods:

  • Review of recent investigations into GCA.
  • Analysis of evidence for immune responses in GCA.
  • Examination of an experimental model of GCA.

Related Experiment Videos

Main Results:

  • Evidence suggests the vasculitic reaction in GCA is an immune response.
  • An antigen within involved artery walls is implicated.
  • Recent studies have significantly advanced the understanding of GCA.

Conclusions:

  • GCA pathogenesis involves an immune response to arterial antigens.
  • Genetic, ethnic, and age factors contribute to GCA risk.
  • Further research, including experimental models, enhances GCA understanding.