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Palmar spiny keratoderma associated with type IV hyperlipoproteinemia

C E Urbani1, L Moneghini

  • 1Servizio di Dermatologia, Ospedale San Raffaele-Resnati Milano, Italy.

Journal of the European Academy of Dermatology and Venereology : JEADV
|June 27, 1998
PubMed
Summary

This study presents a rare case of acquired palmar spiny keratoderma (SK) linked to type IV hyperlipoproteinemia. The findings suggest a potential connection between this skin condition and metabolic disorders.

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Area of Science:

  • Dermatology
  • Medical Genetics
  • Metabolic Disorders

Background:

  • Acquired palmar spiny keratoderma (SK) is a rare skin condition.
  • Type IV hyperlipoproteinemia is a metabolic disorder characterized by elevated triglycerides and VLDL.
  • The association between SK and metabolic impairments has not been previously reported.

Observation:

  • A 35-year-old man presented with acquired palmar spiny keratoderma (SK) developing over 11 years.
  • No history of predisposing factors like topical treatments, Vitamin A derivatives, radiation, arsenic, or sun exposure.
  • Blood tests revealed hypertriglyceridemia and elevated VLDL, consistent with type IV hyperlipoproteinemia.

Findings:

  • Histological examination of SK lesions showed columnar hyperparakeratosis with a hypogranular layer.

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  • The patient's type IV hyperlipoproteinemia was confirmed, with family aggregation for this metabolic defect.
  • This is the first reported case associating acquired spiny keratoderma with a metabolic disorder.

    • Implications:

    • The case highlights the need to consider metabolic screening in patients with acquired SK.
    • Further research is needed to elucidate the underlying mechanisms connecting spiny keratoderma and hyperlipoproteinemia.
    • Understanding this association may lead to new diagnostic and therapeutic approaches for both conditions.