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Related Experiment Videos

Polymeric chitosan-based vesicles for drug delivery

I F Uchegbu1, A G Schätzlein, L Tetley

  • 1Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow, UK.

The Journal of Pharmacy and Pharmacology
|June 27, 1998
PubMed
Summary

Modified glycol chitosan forms stable polymeric vesicles for drug delivery. These biocompatible carriers efficiently encapsulate water-soluble drugs, offering potential for oral and intranasal administration.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Polymer Chemistry

Background:

  • Chitosan is a carbohydrate polymer with potential for drug delivery applications.
  • Modifying chitosan with hydrophobic groups can create amphiphilic polymers capable of self-assembly.
  • Existing vesicle formation theories required a hydrophilic spacer, which this study challenges.

Purpose of the Study:

  • To investigate the ability of modified glycol chitosan to form polymeric vesicles for drug carriers.
  • To explore the potential of these vesicles for oral and intranasal drug administration.
  • To determine if stable polymeric vesicles can be formed without a hydrophilic spacer.

Main Methods:

  • Glycol chitosan was modified with fatty acid pendant groups (11-16 mol%).

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  • Self-assembly into unilamellar polymeric vesicles was induced in the presence of cholesterol.
  • Drug entrapment efficiency was assessed using bleomycin.
  • Biocompatibility and haemocompatibility were evaluated.

    • Main Results:

    • Modified glycol chitosan (palmitoyl glycol chitosan) self-assembled into stable unilamellar polymeric vesicles.
    • These vesicles were biocompatible and haemocompatible.
    • Efficient entrapment of water-soluble drugs, such as bleomycin, was achieved (0.5 units mg(-1) polymer).
    • Stable vesicles were formed without the previously required hydrophilic spacer.

    Conclusions:

    • Glycol chitosan can be modified to form stable, biocompatible polymeric vesicles for drug delivery.
    • These vesicles are suitable for encapsulating water-soluble drugs and show potential for oral and intranasal administration.
    • The study demonstrates that a hydrophilic spacer is not essential for forming stable carbohydrate-based polymeric vesicles.