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Cytotoxic isoflavans from Eysenhardtia polystachya

L Alvarez1, M Y Rios, C Esquivel

  • 1Departamento de Química Orgánica, Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Chamilpa 62210, Cuernavaca, Morelos, Mexico.

Journal of Natural Products
|June 27, 1998
PubMed
Summary

Two new isoflavans isolated from Eysenhardtia polystachya bark show moderate cytotoxic activity. These compounds, along with known constituents, were evaluated for their biological potential.

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Area of Science:

  • Natural Product Chemistry
  • Pharmacology

Background:

  • Eysenhardtia polystachya (Leguminosae) is a plant source of bioactive compounds.
  • Isoflavans are a class of natural products with diverse biological activities.

Purpose of the Study:

  • To isolate and characterize new isoflavans from Eysenhardtia polystachya.
  • To evaluate the cytotoxic, antimicrobial, and insecticidal potential of isolated compounds.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation of new compounds via spectroscopic methods (e.g., NMR, MS).
  • Biological activity screening including cytotoxicity assays against KB cell lines.

Main Results:

  • Two new cytotoxic isoflavans, (3S)-7-hydroxy-2',3',4',5', 8-pentamethoxyisoflavan (1) and (3S)-3',7-dihydroxy-2',4',5', 8-tetramethoxyisoflavan (2), were identified.

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  • Known compounds including stigmasterol and isoduartin were also isolated.
  • Isoflavans 1, 2, and isoduartin demonstrated moderate cytotoxic activity against KB cell lines.

    • Conclusions:

    • Eysenhardtia polystachya bark is a source of novel cytotoxic isoflavans.
    • The isolated isoflavans possess potential for further development as cytotoxic agents.