Related Experiment Videos
Beta-adrenoceptor-stimulated renin release is blunted in old rats
C Baylis1, K Engels, W H Beierwaltes
1Department of Physiology, West Virginia University, Morgantown 26506-9229, USA.
Journal of the American Society of Nephrology : JASN
|June 30, 1998
Abstract:
Plasma renin activity (PRA) was similar in young versus old male Sprague Dawley rats under unstressed conditions (1.3 +/- 0.2 versus 1.8 +/- 0.3 ng angiotensin I/ml per min). Airjet stress increases PRA in young but not old rats (13.9 +/- 3.8 versus 2.9 +/- 0.8 ng angiotensin I/ml per min), respectively. This response is ablated in young rats by beta-adrenoceptor blockade, suggesting that the increased PRA is mediated by beta-adrenoceptors, and this response was blunted in old rats.