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Related Experiment Videos

Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible

C L Mackall1, J A Punt, P Morgan

  • 1Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD, USA. mackallc@pbmac.nci.nih.gov

European Journal of Immunology
|June 30, 1998
PubMed
Summary

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Aging reduces but does not eliminate the thymus's ability to regenerate T cells. Even aged thymi can regenerate significant T cell numbers, suggesting potential for therapies to enhance thymic function in older individuals.

Area of Science:

  • Immunology
  • Aging research
  • T cell regeneration

Background:

  • Thymic involution with age leads to decreased T cell regeneration.
  • The precise impact of aging on thymic regenerative capacity remains unclear.

Purpose of the Study:

  • To quantify the T cell regenerative capacity of aged thymi.
  • To investigate the role of peripheral expansion in T cell regeneration in aged mice.

Main Methods:

  • Bone marrow transplantation (BMT) from young to aged and young mice.
  • Irradiation and T cell-depleted bone marrow administration.
  • Use of TCR-transgenic mice to control for peripheral expansion.

Main Results:

  • Aged thymi showed abnormalities not reversed by young bone marrow.

Related Experiment Videos

  • Aged recipients regenerated fewer splenic T cells and showed increased peripheral expansion.
  • In a setting devoid of peripheral expansion, aged recipients regenerated ~50% of TCR Tg+ cells compared to young recipients.

    • Conclusions:

    • Aged thymi retain a significant capacity for T cell regeneration.
    • Thymic function is reduced, not lost, with age.
    • Therapeutic strategies to enhance thymic function may be viable even in very aged hosts.