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Allergic disorders in primary Sjögren's syndrome
1Department of Rheumatology, Tel Aviv-Sourasky Medical Center, and the Tel Aviv University Sackler School of Medicine, Israel.
Scandinavian Journal of Rheumatology
|June 30, 1998
Summary
Patients with primary Sjögren
Area of Science:
- Rheumatology
- Immunology
- Allergology
Background:
- Allergic disorders are observed in various connective tissue diseases.
- The link between allergy and primary Sjögren's syndrome (pSS) requires further investigation.
Purpose of the Study:
- To determine the prevalence of allergic disorders in patients with primary Sjögren's syndrome.
Main Methods:
- A questionnaire assessed allergic manifestations in 65 primary Sjögren's syndrome patients.
- Comparison was made with control groups: rheumatoid arthritis (n=67), rheumatoid arthritis with sicca symptoms (n=53), and osteoarthritis (n=31).
Main Results:
- 65% of primary Sjögren's syndrome patients reported at least one allergic manifestation, significantly higher than controls (p < 0.01).
- Drug allergy and skin contact allergy were more prevalent in pSS patients (p < 0.05).
- Allergic reactions were more frequent in anti-Ro positive pSS patients (p < 0.05).
Conclusions:
- Allergic disorders, particularly drug and skin contact allergies, are common in primary Sjögren's syndrome.
- Healthcare providers should take detailed allergy histories before prescribing medications to pSS patients.