Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cholesterol, endothelial function and cardiovascular disease

I B Wilkinson1, J R Cockcroft

  • 1Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, UK.

Current Opinion in Lipidology
|June 30, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tri-layered constitutive modelling unveils functional differences between the pig ascending and lower thoracic aorta.

Journal of the mechanical behavior of biomedical materials·2023
Same author

High water vs. ad libitum water intake for autosomal dominant polycystic kidney disease: a randomized controlled feasibility trial.

QJM : monthly journal of the Association of Physicians·2020
Same author

High water vs. ad libitum water intake for autosomal dominant polycystic kidney disease: a randomized controlled feasibility trial.

QJM : monthly journal of the Association of Physicians·2019
Same author

Biomarkers of cardiovascular risk across phenotypes of osteoarthritis.

BMC rheumatology·2019
Same author

Left ventricular mechanics in late second trimester of healthy pregnancy.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2018
Same author

Preconception and early pregnancy maternal haemodynamic changes in healthy women in relation to pregnancy viability.

Human reproduction (Oxford, England)·2017
Same journal

Editorial introduction.

Current opinion in lipidology·2026
Same journal

Heterozygosity for pathogenic variants in familial chylomicronemia syndrome genes: from carrier state to complex trait.

Current opinion in lipidology·2026
Same journal

Premature atherosclerotic cardiovascular disease in the MENA region: economic impact, barriers to care, and policy recommendations for an escalating crisis.

Current opinion in lipidology·2026
Same journal

The role of metabolic profiling and dietary intervention in the early diagnosis and prevention of atherosclerosis.

Current opinion in lipidology·2026
Same journal

A JAK of two trades: beneficial or adverse effects of Janus kinase inhibition for plasma LDL-cholesterol and major adverse cardiovascular events in inflammatory bowel disease patients?

Current opinion in lipidology·2026
Same journal

Inflammation and atherosclerotic cardiovascular disease: where do we go from here?

Current opinion in lipidology·2026
See all related articles

High cholesterol (hypercholesterolaemia) links to endothelial dysfunction and arterial stiffness, increasing cardiovascular disease risk. Arterial stiffness may connect cholesterol, dysfunction, and stroke.

Area of Science:

  • Cardiovascular Science
  • Metabolic Disorders

Background:

  • Hypercholesterolaemia is a known risk factor for cardiovascular disease.
  • Endothelial dysfunction is observed early in atheromatous disease, but causality is unclear.
  • Endothelial function serves as a surrogate marker in clinical trials for cardiovascular mortality.

Purpose of the Study:

  • To explore the relationship between hypercholesterolaemia, endothelial dysfunction, and arterial stiffness.
  • To investigate arterial stiffness as a potential link between metabolic factors and cardiovascular events.

Main Methods:

  • Review of existing literature on hypercholesterolaemia and cardiovascular risk factors.
  • Analysis of studies utilizing endothelial function as a surrogate marker.
  • Examination of recent findings on arterial stiffness as an independent risk factor.

Related Experiment Videos

Main Results:

  • Hypercholesterolaemia is associated with endothelial dysfunction.
  • Arterial stiffness is an emerging independent risk factor for cardiovascular disease.
  • Arterial stiffness may link hypercholesterolaemia, endothelial dysfunction, hypertension, and stroke.

Conclusions:

  • Endothelial dysfunction and arterial stiffness are key indicators in cardiovascular risk assessment.
  • Arterial stiffness offers a potential mechanistic link between hypercholesterolaemia and adverse cardiovascular outcomes.
  • Further research is warranted to elucidate the causal pathways and therapeutic implications.