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Related Experiment Videos

Prosthetic knee Candida parapsilosis infection

M Wada1, H Baba, S Imura

  • 1Department of Orthopaedic Surgery, Fukui Medical School, Shimoaizuki, Japan.

The Journal of Arthroplasty
|June 30, 1998
PubMed
Summary

A Candida parapsilosis infection after knee replacement surgery was successfully treated. Early diagnosis and antifungal irrigation prevented prosthesis removal and joint instability.

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Area of Science:

  • Infectious Diseases
  • Orthopedic Surgery

Background:

  • Total knee arthroplasty (TKA) is a common procedure for knee osteoarthritis.
  • Prosthetic joint infections (PJIs) are a serious complication following TKA.
  • Candida species, though less common than bacterial pathogens, can cause PJIs.

Observation:

  • A 77-year-old male developed knee joint effusion two weeks post-TKA.
  • Cultures of aspirated joint fluid confirmed Candida parapsilosis infection four weeks after surgery.
  • The patient presented with signs of prosthetic joint infection.

Findings:

  • Treatment involved surgical debridement and lavage.
  • Continuous intra-articular fluconazole irrigation was administered for four weeks.
  • Systemic oral fluconazole was given for six months post-irrigation.
  • The patient achieved a favorable outcome with stable prosthesis fixation at three-year follow-up.

Implications:

  • Early identification of Candida parapsilosis is crucial for effective PJI management.
  • Combined surgical intervention with targeted antifungal therapy, including intra-articular irrigation, can be highly effective.
  • This approach may help preserve the prosthesis and prevent long-term joint instability in TKA patients.
  • Highlights the importance of considering fungal pathogens in PJI diagnosis and treatment strategies.

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