Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellular sequences in stealth viruses

W J Martin1

  • 1Center for Complex Infectious Diseases, Rosemead, Calif 91770, USA.

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
|June 30, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The rodent amygdala contributes to the production of cannabinoid-induced antinociception.

Neuroscience·2003
Same author

Mapping alveolar binding sites in vivo using phage peptide libraries.

Gene therapy·2003
Same author

Expression of yeast apurinic/apyrimidinic endonuclease (APN1) protects lung epithelial cells from bleomycin toxicity.

American journal of respiratory cell and molecular biology·2001
Same author

Genetically engineered macrophages expressing IFN-gamma restore alveolar immune function in scid mice.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception.

The Journal of biological chemistry·2001
Same author

PKCgamma contributes to a subset of the NMDA-dependent spinal circuits that underlie injury-induced persistent pain.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same journal

Solitary Fibrous Tumor Arising in Thyroid Follicular Nodular Disease: A Case Report.

Pathobiology : journal of immunopathology, molecular and cellular biology·2026
Same journal

Fumarate Hydratase-deficient Renal Cell Carcinoma - A Multicentric Comprehensive Clinical, Pathological, and Molecular Analysis of 12 Cases.

Pathobiology : journal of immunopathology, molecular and cellular biology·2026
Same journal

Lactate and <italic>Akkermansia muciniphila</italic>: Emerging Roles in Inflammatory Bowel Disease and Colorectal Cancer.

Pathobiology : journal of immunopathology, molecular and cellular biology·2026
Same journal

Stromal Podoplanin Expression as a Prognostic Biomarker in Pancreatic Ductal Adenocarcinoma.

Pathobiology : journal of immunopathology, molecular and cellular biology·2026
Same journal

Cellular Plasticity in Malignant Transformation: Mesothelial Cells.

Pathobiology : journal of immunopathology, molecular and cellular biology·2026
Same journal

Tracking Chemotherapy Effects via ALDH1A1, SOX2, CD44v6, and P-gp Expression in Malignant Ascites from High-Grade Serous Carcinoma.

Pathobiology : journal of immunopathology, molecular and cellular biology·2026
See all related articles

Stealth viruses, cultured from chronic fatigue syndrome (CFS) patients, show significant DNA homology to human cellular genes. This suggests stealth viruses may contribute to genetic diversity in both viral and cellular sequences.

Area of Science:

  • Virology
  • Genetics
  • Molecular Biology

Background:

  • Stealth viruses are a novel class of viruses.
  • These viruses have been isolated from patients with chronic fatigue syndrome (CFS).
  • Previous research indicated significant sequence heterogeneity in stealth virus DNA.

Purpose of the Study:

  • To investigate the genetic makeup of simian cytomegalovirus-derived stealth virus DNA.
  • To identify potential origins and genetic contributions of stealth viruses.

Main Methods:

  • Cloning and sequencing of DNA from stealth virus cultures.
  • Polymerase chain reaction (PCR) amplification using specific primers.
  • Bioinformatic analysis to compare viral sequences with known human cellular genes.

Related Experiment Videos

Main Results:

  • Cloned stealth virus DNA exhibited significant sequence homology to human cellular genes (p values from 4 x 10(-3) to 1 x 10(-20)).
  • PCR analysis of stealth virus isolates from CFS patients yielded diverse products.
  • Some PCR products showed homology to repetitive sequences in the human genome.

Conclusions:

  • Stealth viruses possess genetic material with significant similarity to host cellular genes.
  • The genetic diversity observed in stealth viruses may arise from interactions with cellular DNA.
  • Stealth viruses could play a role in the evolution and genetic diversity of both viral and cellular sequences.