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Mathematical model for the blood coagulation prothrombin time test
M A Khanin1, D V Rakov, A E Kogan
1Laboratory of Theoretical Biology, Russian State University of Technology, Moscow. khanin@landau.ac.ru
Thrombosis Research
|June 30, 1998
Abstract:
A mathematical model for the prothrombin time test is proposed. The time course of clotting factor activation during coagulation was calculated, and the sensitivity of the test to a decrease in the concentrations of coagulation proteins or their activities was studied. The model predicts that only severe coagulation disorders connected with a more than five-fold decrease in the concentrations or activities of the blood coagulation factors can be revealed by the test.