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Related Experiment Videos

Interleukin-17

F Fossiez1, J Banchereau, R Murray

  • 1Schering-Plough, Laboratory for Immunological Research, Dardilly, France.

International Reviews of Immunology
|July 1, 1998
PubMed
Summary
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Interleukin-17 (IL-17) is a cytokine produced by T cells that plays a role in inflammation and immune responses. This study investigates its functions and involvement in processes like kidney graft rejection.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Interleukin-17 (IL-17) is a homodimeric cytokine with restricted expression, primarily from human memory T cells.
  • The IL-17 receptor is widely distributed, with higher abundance in spleen and kidney.
  • IL-17 interacts with Herpesvirus Saimiri (HVS) and influences various cellular responses.

Purpose of the Study:

  • To investigate the biological functions of IL-17.
  • To explore the role of IL-17 in inflammatory processes and immune responses.
  • To examine IL-17's involvement in kidney graft rejection.

Main Methods:

  • In vitro studies involving co-culture systems with various cell types (fibroblasts, epithelial cells, progenitor cells).
  • In vivo studies using IL-17 injection in mice, including IL-6 knockout models.

Related Experiment Videos

  • Analysis of cytokine secretion, cell surface marker expression, and cellular proliferation.

    • Main Results:

    • IL-17 induces secretion of IL-6, IL-8, PGE2, MCP-1, and G-CSF from various adherent cells.
    • IL-17 promotes ICAM-1 expression, T cell proliferation, and neutrophil differentiation.
    • In vivo, IL-17 causes neutrophilia and is implicated in kidney graft rejection.

    Conclusions:

    • IL-17 is a potent inflammatory mediator with diverse cellular effects.
    • Its role in immune responses and inflammatory diseases warrants further investigation.
    • IL-17 is a significant factor in kidney graft rejection.